Indigo 1.33.0

Released 2025-08-14

Features

  • 2890 Conda support

  • 2835 Loading HELM with monomers with multi-character IDs without brackets

  • 2836 Loading monomer NOT from the library as Unknown monomers (in the same manner as it works in IDT)

Bugfixes and improvements

  • 2933 Melting temperature calculation works wrong

  • 2748 Substituents are displayed backwards if appearing on the left of the molecule

  • 2934 Melting temperature should not be defined for one RNA/DNA nucleotide chain lenght

  • 2927 Molecule formula atom order wrong

  • 522 core: replace Obj with standard smart pointer

  • 2937 System doesn’t calculate melting temperature for mix of nucleotides/nucleosides and phosphates

  • 2720 Reaction SMILES lossily handles enhanced stereochemistry

  • 2968 Melting temperature calculation works wrong

  • 2969 Export of unknown for Ketcher monomers works wrong

  • 2923 System doesn’t substract from mass of monomer mass of leaving group atom(s) if an attachment point is occupied

  • 2966 Load from HELM doesn’t work for two side chain connected sequences

  • 2986 Don’t calculate Melting temperature for one pair of double stranded DNA/RNA nucleotides

Full Changelog: https://github.com/epam/Indigo/compare/indigo-1.32.0-rc.1…indigo-1.33.0